An in silico approach combined with in vivo experiments enables the identification of a new protein whose overexpression can compensate for specific respiratory defects in Saccharomyces cerevisiae. - Annie Glatigny; Lise Mathieu; Christopher J. Herbert; Geneviève Dujardin; Brigitte Meunier; Marie-Hélène Mucchielli-Giorgi (BMC Syst. Biol., 2011)