Improving lead time of pharmaceutical production processes using Monte Carlo simulation. - Lukas Gallus Eberle; Hirokazu Sugiyama; Rainer Schmidt 005 (Comput. Chem. Eng., 2014)

Systematic retrofitting methodology for pharmaceutical drug purification processes. - Gioele Casola; Satoshi Yoshikawa; Hayao Nakanishi; Masahiko Hirao; Hirokazu Sugiyama (Comput. Chem. Eng., 2015)

Rigorous approach to scheduling of sterile drug product manufacturing. - Lukas Gallus Eberle; Elisabet Capón-García; Hirokazu Sugiyama; Andreas Graser; Rainer Schmidt 005; Konrad Hungerbühler (Comput. Chem. Eng., 2016)

Data-driven tiered procedure for enhancing yield in drug product manufacturing. - Lukas Gallus Eberle; Hirokazu Sugiyama; Stavros Papadokonstantakis; Andreas Graser; Rainer Schmidt 005; Konrad Hungerbühler (Comput. Chem. Eng., 2016)

Lasing characteristics of GalnAsP SCH-MQW Laser Diode on Directly-bonded InP/Si Substrate. - Takahiro Ishizaki; Kazuki Uchida; Hirokazu Sugiyama; Xu Han; Natsuki Hayasaka; Masaki Aikawa; Masaki Matsuura; Koki Tsushima; Takuto Shirai; Kazuhiko Shimomura (OECC/PSC, 2019)

Lasing Characteristics of GalnAsP SCH MQW High-mesa Laser on Silicon Substrate. - Koki Tsushima; Kazuki Uchida; Xu Han; Hirokazu Sugiyama; Masaki Aikawa; Natsuki Hayasaka; Masaki Matsuura; Takahiro Ishizaki; Takuto Shirai; Kazuhiko Shimomura (OECC/PSC, 2019)

Data mining algorithm for pre-processing biopharmaceutical drug product manufacturing records. - Gioele Casola; Christian Siegmund; Markus Mattern; Hirokazu Sugiyama (Comput. Chem. Eng., 2019)

Alternative generation and multiobjective evaluation using a design framework: Case study on sterile filling processes of biopharmaceuticals. - Haruku Shirahata; Sara Badr; Shant Dakessian; Hirokazu Sugiyama (Comput. Chem. Eng., 2019)

Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals. - Haruku Shirahata; Masahiko Hirao; Hirokazu Sugiyama (Comput. Chem. Eng., 2019)

Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation. - Yusuke Hayashi; Ikki Horiguchi; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2020)

Integrated design of biopharmaceutical manufacturing processes: Operation modes and process configurations for monoclonal antibody production. - Sara Badr; Kozue Okamura; Nozomi Takahashi; Vera Ubbenjans; Haruku Shirahata; Hirokazu Sugiyama (Comput. Chem. Eng., 2021)

Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells. - Yusuke Hayashi; Ikki Horiguchi; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2021)

Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality. - Yusuke Hayashi; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2022)

Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation. - Junu Kim; Hironori Yonekura; Takeaki Watanabe; Satoshi Yoshikawa; Hayao Nakanishi; Sara Badr; Hirokazu Sugiyama (Comput. Chem. Eng., 2022)

A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells. - Benedikt X. Scholz; Yusuke Hayashi; Isuru A. Udugama; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2022)

Agile process systems engineering education: What to teach, and how to teach. - Daniel R. Lewin; Emilia M. Kondili; Ian T. Cameron; Grégoire Léonard; Seyed Soheil Mansouri; Fernando Gomes Martins; Luis A. Ricardez-Sandoval; Hirokazu Sugiyama; Edwin Zondervan (Comput. Chem. Eng., 2023)

Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes. - Kensaku Matsunami; Tomohiro Miura; Keita Yaginuma; Shuichi Tanabe; Sara Badr; Hirokazu Sugiyama (Comput. Chem. Eng., 2023)

A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation. - Benedikt X. Scholz; Yusuke Hayashi; Isuru A. Udugama; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2023)

The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production. - Isuru A. Udugama; Sara Badr; Keita Hirono; Benedikt X. Scholz; Yusuke Hayashi; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2023)

Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior. - Kozue Okamura; Kota Oishi; Sara Badr; Akira Yamada 009; Hirokazu Sugiyama (Comput. Chem. Eng., 2024)

Model-based design of mesenchymal stem cell seeding-cultivation-passage processes considering dynamics and variabilities. - Keita Hirono; Yusuke Hayashi; Masahiro Kino-oka; Hirokazu Sugiyama (Comput. Chem. Eng., 2025)

Anomaly detection for drug product manufacturing considering data limitations and shifts: A case study on industrial freeze-dryers. - Gianluca Lombardini; Sara Badr; Christian Schmid; Stephanie Knüppel; Hirokazu Sugiyama (Comput. Chem. Eng., 2025)