Ten simple rules for building and maintaining sustainable high-performance computing infrastructure for research in resource-limited settings. - Ronald Galiwango; Christopher J. Whalen; Grace Kebirungi; Mugume T. Atwine; Rodgers Kimera; Alfred Ssekagiri; Timothy W. Kimbowa; Edward Lukyamuzi; Mike Nsubuga; Lloyd Ssentongo; Henry Mutegeki; John M. Fonner; et al. (PLoS Comput. Biol., 2025)