An efficient synthesis of a rationally designed 1, 5 disubstituted imidazole AT1 Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies. - George Agelis; Panagiota Roumelioti; Amalia Resvani; Serdar Durdagi; Maria-Eleni Androutsou; Konstantinos Kelaidonis; Demetrios Vlahakos; Thomas M. Mavromoustakos; John Matsoukas (J. Comput. Aided Mol. Des., 2010)