PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes. - Liskin Swint-Kruse; Larissa L. Dougherty; Braelyn Page; Tiffany Wu; Pierce T. O'Neil; Charulata B. Prasannan; Cody Timmons; Qingling Tang; Daniel Joseph Parente; Shwetha Sreenivasan; Todd Holyoak; Aron W. Fenton (Database J. Biol. Databases Curation, 2023)