Multi-factor data normalization enables the detection of copy number aberrations in amplicon sequencing data. - Valentina Boeva; Tatiana G. Popova; Maxime Lienard; Sebastien Toffoli; Maud Kamal; Christophe Le Tourneau; David Gentien; Nicolas Servant; Pierre Gestraud; Thomas Rio Frio; Philippe Hupé; Emmanuel Barillot; et al. (Bioinform., 2014)