David E. Clark

According to our database, David E. Clark authored at least 15 papers between 1993 and 2020.

Collaborative distances:

• Dijkstra number of five.
• Erdős number of four.

2020

Virtual Screening: Is Bigger Always Better? Or Can Small Be Beautiful?

David E. Clark

J. Chem. Inf. Model., 2020

2006

Similarity Searching in Databases of Flexible 3D Structures Using Autocorrelation Vectors Derived from Smoothed Bounded Distance Matrices.

Nicholas Rhodes, David E. Clark, Peter Willett

J. Chem. Inf. Model., 2006

2000

Enhancing the Hit-to-Lead Properties of Lead Optimization Libraries.

Stephen D. Pickett, Iain M. McLay, David E. Clark

J. Chem. Inf. Comput. Sci., 2000

1997

A comparison of heuristic search algorithms for molecular docking.

David R. Westhead, David E. Clark, Christopher W. Murray

J. Comput. Aided Mol. Des., 1997

PRO_SELECT: Combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology.

Christopher W. Murray, David E. Clark, Timothy R. Auton, Michael A. Firth, Jin Li, Richard A. Sykes, Bohdan Waszkowycz, David R. Westhead, Stephen C. Young

J. Comput. Aided Mol. Des., 1997

1996

MOLMAKER: De Novo Generation of 3D Databases for Use in Drug Design.

David E. Clark, Michael A. Firth, Christopher W. Murray

J. Chem. Inf. Comput. Sci., 1996

Active-site-directed 3D database searching: Pharmacophore extraction and validation of hits.

David E. Clark, David R. Westhead, Richard A. Sykes, Christopher W. Murray

J. Comput. Aided Mol. Des., 1996

Evolutionary algorithms in computer-aided molecular design.

David E. Clark, David R. Westhead

J. Comput. Aided Mol. Des., 1996

1995

PRO_LIGAND: An Approach to de Novo Molecular Design, 5. Tools for the Analysis of Generated Structures.

David E. Clark, Christopher W. Murray

J. Chem. Inf. Comput. Sci., 1995

PRO_LIGAND: An approach to de novo molecular design. 3. A genetic algorithm for structure refinement.

David R. Westhead, David E. Clark, David Frenkel, Jin Li, Christopher W. Murray, Barry Robson, Bohdan Waszkowycz

J. Comput. Aided Mol. Des., 1995

PRO_LIGAND: An approach to de novo molecular design. 6. Flexible fitting in the design of peptides.

Christopher W. Murray, David E. Clark, Deirdre G. Byrne

J. Comput. Aided Mol. Des., 1995

PRO_LIGAND: An approach to de novo molecular design. 4. Application to the design of peptides.

David Frenkel, David E. Clark, Jin Li, Christopher W. Murray, Barry Robson, Bohdan Waszkowycz, David R. Westhead

J. Comput. Aided Mol. Des., 1995

PRO_LIGAND: An approach to de novo molecular design. 1. Application to the design of organic molecules.

David E. Clark, David Frenkel, Stephen A. Levy, Jin Li, Christopher W. Murray, Barry Robson, Bohdan Waszkowycz, David R. Westhead

J. Comput. Aided Mol. Des., 1995

1994

Pharmacophoric pattern matching in files of three-dimensional chemical structures: Comparison of conformational-searching algorithms for flexible searching.

David E. Clark, Gareth Jones, Peter Willett, Peter W. Kenny, Robert C. Glen

J. Chem. Inf. Comput. Sci., 1994

1993

Searching Databases of Two-Dimensional and Three-Dimensional Chemical Structures Using Genetic Algorithms.

Gareth Jones, Robert D. Brown, David E. Clark, Peter Willett, Robert C. Glen

Proceedings of the 5th International Conference on Genetic Algorithms, 1993