Bryan L. Roth

According to our database, Bryan L. Roth authored at least 6 papers between 2009 and 2023.

Collaborative distances:

• Dijkstra number of five.
• Erdős number of four.

2023

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.

Leslie Salas-Estrada, Davide Provasi, Xing Qiu, Husnu Ümit Kaniskan, Xi-Ping Huang, Jeffrey F. Diberto, João Marcelo Lamim Ribeiro, Jian Jin, Bryan L. Roth, Marta Filizola

J. Chem. Inf. Model., August, 2023

2016

Structure-based discovery of opioid analgesics with reduced side effects.

Aashish Manglik, Henry Lin, Dipendra K. Aryal, John D. McCorvy, Daniela Dengler, Gregory Corder, Anat Levit, Ralf C. Kling, Viachaslau Bernat, Harald Hübner, Xi-Ping Huang, Maria F. Sassano, Patrick M. Giguère, Stefan Löber, Da Duan, Grégory Scherrer, Brian K. Kobilka, Peter Gmeiner, Bryan L. Roth, Brian K. Shoichet

Nat., 2016

2015

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya D. Nikolova, Martilias S. Farrell, Sheng Wang, Thomas J. Mangano, Deepak A. Deshpande, Alice Jiang, Raymond B. Penn, Jian Jin, Beverly H. Koller, Terry Kenakin, Brian K. Shoichet, Bryan L. Roth

Nat., 2015

2014

Application of Quantitative Structure-Activity Relationship Models of 5-HT_1A Receptor Binding to Virtual Screening Identifies Novel and Potent 5-HT_1A Ligands.

Man Luo, Xiang Simon Wang, Bryan L. Roth, Alexander Golbraikh, Alexander Tropsha

J. Chem. Inf. Model., 2014

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data.

Denis Fourches, Maria F. Sassano, Bryan L. Roth, Alexander Tropsha

Bioinform., 2014

2009

Novel Inhibitors of Human Histone Deacetylase (HDAC) Identified by QSAR Modeling of Known Inhibitors, Virtual Screening, and Experimental Validation.

Hao Tang, Xiang S. Wang, Xi-Ping Huang, Bryan L. Roth, Kyle V. Butler, Alan P. Kozikowski, Mira Jung, Alexander Tropsha

J. Chem. Inf. Model., 2009