Ottavia Spiga

According to our database, Ottavia Spiga authored at least 14 papers between 2005 and 2026.

Collaborative distances:

• Dijkstra number of four.
• Erdős number of four.

2026

Knowledge Graph Extraction from Biomedical Literature for Alkaptonuria Rare Disease.

Giang Pham, Rebecca Finetti, Caterina Graziani, Bianca Roncaglia, Asma Bendjeddou, Linda Brodo, Sara Brunetti, Moreno Falaschi, Stefano Forti, Silvia Giulia Galfrè, Paolo Milazzo, Corrado Priami, Annalisa Santucci, Ottavia Spiga, Alina Sîrbu

CoRR, March, 2026

2025

Machine Learning for Predicting the Drug-to-Antibody Ratio (DAR) in the Synthesis of Antibody-Drug Conjugates (ADCs).

Lorenzo Angiolini, Fabrizio Manetti, Ottavia Spiga, Andrea Tafi, Anna Visibelli, Elena Petricci

J. Chem. Inf. Model., 2025

Predicting therapy dropout in chronic pain management: a machine learning approach to cannabis treatment.

Anna Visibelli, Rebecca Finetti, Bianca Roncaglia, Paolo Poli, Ottavia Spiga, Annalisa Santucci

Frontiers Artif. Intell., 2025

2022

Structural Bioinformatic Survey of Protein-Small Molecule Interfaces Delineates the Role of Glycine in Surface Pocket Formation.

Pietro Bongini, Neri Niccolai, Alfonso Trezza, Guido Mangiavacchi, Annalisa Santucci, Ottavia Spiga, Monica Bianchini, Simone Gardini

IEEE ACM Trans. Comput. Biol. Bioinform., 2022

Bioinformatics Approaches to Predict Mutation Effects in the Binding Site of the Proangiogenic Molecule CD93.

Vittoria Cicaloni, Malancha Karmakar, Luisa Frusciante, Francesco Pettini, Anna Visibelli, Maurizio Orlandini, Federico Galvagni, Maurizio Mongiat, Michael Silk, Federica Nardi, David B. Ascher, Annalisa Santucci, Ottavia Spiga

Frontiers Bioinform., 2022

2021

Structural bioinformatics survey on disease-inducing missense mutations.

Pietro Bongini, Simone Gardini, Monica Bianchini, Ottavia Spiga, Neri Niccolai

J. Bioinform. Comput. Biol., 2021

Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease.

Ottavia Spiga, Vittoria Cicaloni, Giovanna Maria Dimitri, Francesco Pettini, Daniela Braconi, Andrea Bernini, Annalisa Santucci

Briefings Bioinform., 2021

2020

AKUImg: A database of cartilage images of Alkaptonuria patients.

Alberto Rossi, Giorgia Giacomini, Vittoria Cicaloni, Silvia Galderisi, Maria Serena Milella, Andrea Bernini, Lia Millucci, Ottavia Spiga, Monica Bianchini, Annalisa Santucci

Comput. Biol. Medicine, 2020

Transient pockets as mediators of gas molecules routes inside proteins: The case study of dioxygen pathway in homogentisate 1, 2-dioxygenase and its implication in Alkaptonuria development.

Andrea Bernini, Silvia Galderisi, Ottavia Spiga, Chukwudi Onyekachi Amarabom, Annalisa Santucci

Comput. Biol. Chem., 2020

2018

A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria.

Ottavia Spiga, Vittoria Cicaloni, Andrea Zatkova, Lia Millucci, Giulia Bernardini, Andrea Bernini, Barbara Marzocchi, Monica Bianchini, Andrea Zugarini, Alberto Rossi, Matteo Zazzeri, Alfonso Trezza, Bruno Frediani, Lakshminarayan Ranganath, Daniela Braconi, Annalisa Santucci

Comput. Biol. Medicine, 2018

2017

ApreciseKUre: an approach of Precision Medicine in a Rare Disease.

Ottavia Spiga, Vittoria Cicaloni, Andrea Bernini, Andrea Zatkova, Annalisa Santucci

BMC Medical Informatics Decis. Mak., 2017

Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1, 2-dioxygenase mutants at the base of rare disease Alkaptonuria.

Andrea Bernini, Silvia Galderisi, Ottavia Spiga, Giulia Bernardini, Neri Niccolai, Fabrizio Manetti, Annalisa Santucci

Comput. Biol. Chem., 2017

2013

ProCoCoA: A quantitative approach for analyzing protein core composition.

Silvia Bottini, Andrea Bernini, Matteo De Chiara, Diego Garlaschelli, Ottavia Spiga, Marco Dioguardi, Elisa Vannuccini, Anna Tramontano, Neri Niccolai

Comput. Biol. Chem., 2013

2005

Three-dimensional computation of atom depth in complex molecular structures.

Daniele Varrazzo, Andrea Bernini, Ottavia Spiga, Arianna Ciutti, Stefano Chiellini, Vincenzo Venditti, Luisa Bracci, Neri Niccolai

Bioinform., 2005