Silvio C. E. Tosatto

Orcid: 0000-0003-4525-7793

According to our database1, Silvio C. E. Tosatto authored at least 75 papers between 2005 and 2024.

Collaborative distances:
  • Dijkstra number2 of four.
  • Erdős number3 of four.



In proceedings 
PhD thesis 


Online presence:



Best practices for the manual curation of intrinsically disordered proteins in DisProt.
Database J. Biol. Databases Curation, January, 2024

FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins.
Nucleic Acids Res., July, 2023

CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins.
Nucleic Acids Res., July, 2023

RING-PyMOL: residue interaction networks of structural ensembles and molecular dynamics.
Bioinform., May, 2023

MobiDB: 10 years of intrinsically disordered proteins.
Nucleic Acids Res., January, 2023

InterPro in 2022.
Nucleic Acids Res., January, 2023

CAFA-evaluator: A Python Tool for Benchmarking Ontological Classification Methods.
CoRR, 2023

PDBe-KB: collaboratively defining the biological context of structural data.
Nucleic Acids Res., 2022

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
Nucleic Acids Res., 2022

ECO: the Evidence and Conclusion Ontology, an update for 2022.
Nucleic Acids Res., 2022

FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins.
Nucleic Acids Res., 2022

FuzDB: a new phase in understanding fuzzy interactions.
Nucleic Acids Res., 2022

RING 3.0: fast generation of probabilistic residue interaction networks from structural ensembles.
Nucleic Acids Res., 2022

Mocafe: a comprehensive Python library for simulating cancer development with Phase Field Models.
Bioinform., 2022

ProSeqViewer: an interactive, responsive and efficient TypeScript library for visualization of sequences and alignments in web applications.
Bioinform., 2022

MobiDB: intrinsically disordered proteins in 2021.
Nucleic Acids Res., 2021

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures.
Nucleic Acids Res., 2021

Pfam: The protein families database in 2021.
Nucleic Acids Res., 2021

The MemMoRF database for recognizing disordered protein regions interacting with cellular membranes.
Nucleic Acids Res., 2021

The InterPro protein families and domains database: 20 years on.
Nucleic Acids Res., 2021

MobiDB-lite 3.0: fast consensus annotation of intrinsic disorder flavors in proteins.
Bioinform., 2021

APICURON: a database to credit and acknowledge the work of biocurators.
Database J. Biol. Databases Curation, 2021

Assessing predictors for new post translational modification sites: A case study on hydroxylation.
PLoS Comput. Biol., 2020

PhaSePro: the database of proteins driving liquid?liquid phase separation.
Nucleic Acids Res., 2020

PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins.
Nucleic Acids Res., 2020

DisProt: intrinsic protein disorder annotation in 2020.
Nucleic Acids Res., 2020

Exploring Conformational Space with Thermal Fluctuations Obtained by Normal-Mode Analysis.
J. Chem. Inf. Model., 2020

Recommendations for machine learning validation in biology.
CoRR, 2020

The Feature-Viewer: a visualization tool for positional annotations on a sequence.
Bioinform., 2020

Disentangling the complexity of low complexity proteins.
Briefings Bioinform., 2020

Genotype-phenotype relations of the von Hippel-Lindau tumor suppressor inferred from a large-scale analysis of disease mutations and interactors.
PLoS Comput. Biol., 2019

INGA 2.0: improving protein function prediction for the dark proteome.
Nucleic Acids Res., 2019

InterPro in 2019: improving coverage, classification and access to protein sequence annotations.
Nucleic Acids Res., 2019

The Pfam protein families database in 2019.
Nucleic Acids Res., 2019

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.
Nucleic Acids Res., 2018

RepeatsDB-lite: a web server for unit annotation of tandem repeat proteins.
Nucleic Acids Res., 2018

Mobi 2.0: an improved method to define intrinsic disorder, mobility and linear binding regions in protein structures.
Bioinform., 2018

A comprehensive assessment of long intrinsic protein disorder from the DisProt database.
Bioinform., 2018

Where differences resemble: sequence-feature analysis in curated databases of intrinsically disordered proteins.
Database J. Biol. Databases Curation, 2018

PhytoTypeDB: a database of plant protein inter-cultivar variability and function.
Database J. Biol. Databases Curation, 2018

Conformational diversity analysis reveals three functional mechanisms in proteins.
PLoS Comput. Biol., 2017

DisProt 7.0: a major update of the database of disordered proteins.
Nucleic Acids Res., 2017

SODA: prediction of protein solubility from disorder and aggregation propensity.
Nucleic Acids Res., 2017

RepeatsDB 2.0: improved annotation, classification, search and visualization of repeat protein structures.
Nucleic Acids Res., 2017

InterPro in 2017 - beyond protein family and domain annotations.
Nucleic Acids Res., 2017

FELLS: fast estimator of latent local structure.
Bioinform., 2017

MobiDB-lite: fast and highly specific consensus prediction of intrinsic disorder in proteins.
Bioinform., 2017

The RING 2.0 web server for high quality residue interaction networks.
Nucleic Acids Res., 2016

Tools and data services registry: a community effort to document bioinformatics resources.
Nucleic Acids Res., 2016

Correct machine learning on protein sequences: a peer-reviewing perspective.
Briefings Bioinform., 2016

MobiDB 2.0: an improved database of intrinsically disordered and mobile proteins.
Nucleic Acids Res., 2015

INGA: protein function prediction combining interaction networks, domain assignments and sequence similarity.
Nucleic Acids Res., 2015

Comprehensive large-scale assessment of intrinsic protein disorder.
Bioinform., 2015

The Victor C++ library for protein representation and advanced manipulation.
Bioinform., 2015

PASTA 2.0: an improved server for protein aggregation prediction.
Nucleic Acids Res., 2014

RepeatsDB: a database of tandem repeat protein structures.
Nucleic Acids Res., 2014

Analysis and consensus of currently available intrinsic protein disorder annotation sources in the MobiDB database.
BMC Bioinform., 2013

RAPHAEL: recognition, periodicity and insertion assignment of solenoid protein structures.
Bioinform., 2012

ESpritz: accurate and fast prediction of protein disorder.
Bioinform., 2012

Bluues server: electrostatic properties of wild-type and mutated protein structures.
Bioinform., 2012

MobiDB: a comprehensive database of intrinsic protein disorder annotations.
Bioinform., 2012

In silico blood genotyping from exome sequencing data.
Proceedings of the Workshop on Annotation, 2012

CSpritz: accurate prediction of protein disorder segments with annotation for homology, secondary structure and linear motifs.
Nucleic Acids Res., 2011

RING: networking interacting residues, evolutionary information and energetics in protein structures.
Bioinform., 2011

FRASS: the web-server for RNA structural comparison.
BMC Bioinform., 2010

MOBI: a web server to define and visualize structural mobility in NMR protein ensembles.
Bioinform., 2010

REPETITA: detection and discrimination of the periodicity of protein solenoid repeats by discrete Fourier transform.
Bioinform., 2009

TESE: generating specific protein structure test set ensembles.
Bioinform., 2008

TAP score: torsion angle propensity normalization applied to local protein structure evaluation.
BMC Bioinform., 2007

Spritz: a server for the prediction of intrinsically disordered regions in protein sequences using kernel machines.
Nucleic Acids Res., 2006

Improving the quality of protein structure models by selecting from alignment alternatives.
BMC Bioinform., 2006

The Victor/FRST Function for Model Quality Estimation.
J. Comput. Biol., 2005

A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators.
BMC Bioinform., 2005

The SSEA server for protein secondary structure alignment.
Bioinform., 2005

Decomposing protein networks into domain-domain interactions.
Proceedings of the ECCB/JBI'05 Proceedings, Fourth European Conference on Computational Biology/Sixth Meeting of the Spanish Bioinformatics Network (Jornadas de BioInformática), Palacio de Congresos, Madrid, Spain, September 28, 2005