Christine A. Orengo

  • University College London, Institute of Structural and Molecular Biology, UK

According to our database1, Christine A. Orengo authored at least 80 papers between 1996 and 2021.

Collaborative distances:



In proceedings 
PhD thesis 


Online presence:



CATH: increased structural coverage of functional space.
Nucleic Acids Res., 2021

The InterPro protein families and domains database: 20 years on.
Nucleic Acids Res., 2021

Clustering FunFams using sequence embeddings improves EC purity.
Bioinform., 2021

CATH functional families predict functional sites in proteins.
Bioinform., 2021

The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies.
Briefings Bioinform., 2021

PDBe-KB: a community-driven resource for structural and functional annotations.
Nucleic Acids Res., 2020

Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation.
Nucleic Acids Res., 2020

The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences.
Bioinform., 2020

Protein Structure Classification.
Proceedings of the Encyclopedia of Bioinformatics and Computational Biology - Volume 2, 2019

CATH: expanding the horizons of structure-based functional annotations for genome sequences.
Nucleic Acids Res., 2019

InterPro in 2019: improving coverage, classification and access to protein sequence annotations.
Nucleic Acids Res., 2019

FunFam protein families improve residue level molecular function prediction.
BMC Bioinform., 2019

Associating Protein Domains with Biological Functions: A Tripartite Network Approach.
Proceedings of the Bioinformatics and Biomedical Engineering, 2019

Gene3D: Extensive prediction of globular domains in proteins.
Nucleic Acids Res., 2018

Analysis of temporal transcription expression profiles reveal links between protein function and developmental stages of Drosophila melanogaster.
PLoS Comput. Biol., 2017

InterPro in 2017 - beyond protein family and domain annotations.
Nucleic Acids Res., 2017

CATH: an expanded resource to predict protein function through structure and sequence.
Nucleic Acids Res., 2017

ISCB's initial reaction to New England Journal of Medicine editorial on data sharing.
Bioinform., 2017

Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases.
PLoS Comput. Biol., 2016

ISCB's Initial Reaction to <i>The New England Journal of Medicine</i> Editorial on Data Sharing.
PLoS Comput. Biol., 2016

Gene3D: expanding the utility of domain assignments.
Nucleic Acids Res., 2016

CATH: comprehensive structural and functional annotations for genome sequences.
Nucleic Acids Res., 2015

The InterPro protein families database: the classification resource after 15 years.
Nucleic Acids Res., 2015

Genome3D: exploiting structure to help users understand their sequences.
Nucleic Acids Res., 2015

CATH FunFHMMer web server: protein functional annotations using functional family assignments.
Nucleic Acids Res., 2015

FUN-L: gene prioritization for RNAi screens.
Bioinform., 2015

Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.
Bioinform., 2015

Gene3D: Multi-domain annotations for protein sequence and comparative genome analysis.
Nucleic Acids Res., 2014

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.
Nucleic Acids Res., 2013

Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.
Nucleic Acids Res., 2013

Protein function prediction using domain families.
BMC Bioinform., 2013

Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies.
PLoS Comput. Biol., 2012

Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis.
Nucleic Acids Res., 2012

InterPro in 2011: new developments in the family and domain prediction database.
Nucleic Acids Res., 2012

FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies.
Nucleic Acids Res., 2012

The Gene3D Web Services: a platform for identifying, annotating and comparing structural domains in protein sequences.
Nucleic Acids Res., 2011

Extending CATH: increasing coverage of the protein structure universe and linking structure with function.
Nucleic Acids Res., 2011

Characterization of pathogenic germline mutations in human Protein Kinases.
BMC Bioinform., 2011

Finding the "Dark Matter" in Human and Yeast Protein Network Prediction and Modelling.
PLoS Comput. Biol., 2010

Gene3D: merging structure and function for a Thousand genomes.
Nucleic Acids Res., 2010

A fast and automated solution for accurately resolving protein domain architectures.
Bioinform., 2010

FLORA: A Novel Method to Predict Protein Function from Structure in Diverse Superfamilies.
PLoS Comput. Biol., 2009

InterPro: the integrative protein signature database.
Nucleic Acids Res., 2009

The CATH classification revisited - architectures reviewed and new ways to characterize structural divergence in superfamilies.
Nucleic Acids Res., 2009

An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D.
BMC Bioinform., 2009

Gene3D: comprehensive structural and functional annotation of genomes.
Nucleic Acids Res., 2008

ISPIDER Central: an integrated database web-server for proteomics.
Nucleic Acids Res., 2008

FFPred: an integrated feature-based function prediction server for vertebrate proteomes.
Nucleic Acids Res., 2008

LigASite - a database of biologically relevant binding sites in proteins with known <i>apo</i>-structures.
Nucleic Acids Res., 2008

CATHEDRAL: A Fast and Effective Algorithm to Predict Folds and Domain Boundaries from Multidomain Protein Structures.
PLoS Comput. Biol., 2007

Predicting Protein Function with Hierarchical Phylogenetic Profiles: The Gene3D Phylo-Tuner Method Applied to Eukaryotic Genomes.
PLoS Comput. Biol., 2007

Inferring Function Using Patterns of Native Disorder in Proteins.
PLoS Comput. Biol., 2007

New developments in the InterPro database.
Nucleic Acids Res., 2007

The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution.
Nucleic Acids Res., 2007

Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint.
BMC Bioinform., 2007

Establishing a major cause of discrepancy in the calibration of Affymetrix GeneChips.
BMC Bioinform., 2007

Methods of remote homology detection can be combined to increase coverage by 10% in the midnight zone.
Bioinform., 2007

Gene3D: modelling protein structure, function and evolution.
Nucleic Acids Res., 2006

Improved Robustness in Time Series Analysis of Gene Expression Data by Polynomial Model Based Clustering.
Proceedings of the Computational Life Sciences II, 2006

The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis.
Nucleic Acids Res., 2005

Cluster Based Integration of Heterogeneous Biological Databases Using the AutoMed Toolkit.
Proceedings of the Data Integration in the Life Sciences, Second InternationalWorkshop, 2005

EyeSite: a semi-automated database of protein families in the eye.
Nucleic Acids Res., 2004

A practical and robust sequence search strategy for structural genomics target selection.
Bioinform., 2004

A structural perspective on genome evolution.
Proceedings of the Eighth Annual International Conference on Computational Molecular Biology, 2004

Microeconomic Principles Explain an Optimal Genome Size in Bacteria.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

Consensus Clustering and Functional Interpretation of Gene Expression Data.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

BioMap: Gene Family based Integration of Heterogeneous Biological Databases Using AutoMed Metadata.
Proceedings of the 15th International Workshop on Database and Expert Systems Applications (DEXA 2004), with CD-ROM, 30 August, 2004

The CATH database: an extended protein family resource for structural and functional genomics.
Nucleic Acids Res., 2003

Gene3D: structural assignments for the biologist and bioinformaticist alike.
Nucleic Acids Res., 2003

Recognizing the fold of a protein structure.
Bioinform., 2003

A Structural Perspective on Genome Evolution(Invited Talk).
Proceedings of the German Conference on Bioinformatics, 2003

A framework for modelling virus gene expression data.
Intell. Data Anal., 2002

PFDB: a generic protein family database integrating the CATH domain structure database with sequence based protein family resources.
Bioinform., 2002

A rapid classification protocol for the CATH Domain Database to support structural genomics.
Nucleic Acids Res., 2001

VIDA: a virus database system for the organization of animal virus genome open reading frames.
Nucleic Acids Res., 2001

A Framework for Modelling Short, High-Dimensional Multivariate Time Series: Preliminary Results in Virus Gene Expression Data Analysis.
Proceedings of the Advances in Intelligent Data Analysis, 4th International Conference, 2001

Assigning genomic sequences to CATH.
Nucleic Acids Res., 2000

The CATH Database provides insights into protein structure/function relationships.
Nucleic Acids Res., 1999

[Invited Lecture] Protein Folds and Functions.
Proceedings of the German Conference on Bioinformatics, 1998

A Protein Structure Comparison Methodology.
Comput. Chem., 1996